In the present paper, an integrated intervention system applicable to concrete-framed buildings is presented. The purpose of the intervention is to improve both the seismic and the energetic behaviour of such buildings using cross-laminated timber (CLT) panels. Two alternative intervention configurations with different levels of invasiveness are described. Considering a double-wythe masonry-infilled frame, the most invasive configuration consists in the replacement of the external masonry wythe

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... with the CLT panel, while the least invasive configuration consists in the arrangement of the CLT panel from the outside without removing the wythes. The technical details and implementation procedures were studied, considering functionality and disturbance to occupants. An isolated one-storey-one-bay frame was used as a reference for the seismic and thermal analyses. Subsequently, the two intervention configurations were applied to a case-study building by identifying two alternative intervention strategies. The obtained results showed that the proposed integrated intervention approach can significantly reduce both the seismic vulnerability and the energy consumption of concrete buildings.