a 厦门大学化学系 厦门 361005) ( b 厦门大学药学院 厦门 361102) ( c 宁波大学新药技术研究院 宁波 315211) 摘要 具有五元环和三配体结构的五配位氧磷烷(ab 2 )在碱催化条件下自发进行分子间的配体交换反应, 产生不同配体 组合的全部三种五配位氧磷烷(a 3 , b 3 和 a 2 b). 如果把其中 a 3 与 b 3 作为父代分子, 其配体交换产生的五配位氧磷烷 a 2 b 和 ab 2 可以视作子代分子, 从而自发实现了分子结构的多样化. 因此, 五配位氧磷烷分子间配体交换反应可以作为研究 生命过程中具有五配位磷中间体结构化学性质的模型, 对理解基因转录和生命信息储存等过程中涉及的 RNA 分子剪 接、水解和融合等重要生命过程的分子机制提供了重要依据. Abstract Penta-coordinated phosphoranes (ab 2 ) with a five-member cycle and three ligands would simultaneously exchange with themselves under base

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... atalysis to form three different penta-oxy phosphoranes with all the combinatorial ligands referred as a 3 , b 3 , and a 2 b. If we consider a 3 and b 3 as parents, the products obtained from exchange, namely a 2 b and ab 2 , could be regarded as the offspring of the first generation, leading to the diversified chemical structures. Thus, these fascinating reactions could be considered as a promising chemical model for studying the unique chemistry of possible penta-coordinated phosphorus intermediates in the process of RNA self-splicing, hydrolysis and fusion for gene transcription and biological information storage.