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The association between the Deformed Wing Virus and the parasitic mite Varroa destructor has been identified as a major cause of worldwide honey bee colony losses. The mite acts as a vector of the viral pathogen and can trigger its replication in infected bees. However, the mechanistic details underlying this tripartite interaction are still poorly defined, and, in particular, the causes of viral proliferation in mite infested bees. Here we develop and test a novel hypothesis - grounded indoi:10.1101/257667 fatcat:mj3xg75hj5atxanv52rvgtiiae