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Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1. is essential for host defense, but it can injure tissues and compromise organ function. TNF-␣ and IL-1 (␣ and ␤) are early response cytokines that facilitate inflammation. To determine the roles of these cytokines with overlapping functions, we generated mice deficient in all of the three receptors mediating their effects (TNFR1, TNFR2,doi:10.1152/ajplung.00353.2003 pmid:14966082 fatcat:wrcuyyw6r5e2flncgepsrxblny