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The Digital Mouse: why computational modelling of mouse models of disease can improve translation
[article]
2020
bioRxiv
pre-print
Computational models can be used to study the mechanistic phenomena of disease. Current mechanistic computer simulation models mainly focus on (patho)physiology in humans. However, often data and experimental findings from preclinical studies are used as input to develop such models. Biological processes underlying age-related chronic diseases are studied in animal models. The translation of these observations to clinical applications is not trivial. As part of a group of international
doi:10.1101/2020.05.04.075812
fatcat:xaznq4zoavbclcjexxmfzzdj3e