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The different environments that humans experience are likely to impact physiology and disease susceptibility. In order to estimate the magnitude of the impact of environment on transcript abundance, we examined gene expression in peripheral blood leukocyte samples from 46 desert nomadic, mountain agrarian and coastal urban Moroccan Amazigh individuals. Despite great expression heterogeneity in humans, as much as one third of the leukocyte transcriptome was found to be associated withdoi:10.1371/journal.pgen.1000052 pmid:18404217 pmcid:PMC2290968 fatcat:caa2dwssdfeitou56nnfnhv6gu