Structural Probes in Quadruplex Nucleic Acid Structure Determination by NMR

Andreas Karsisiotis, Mateus Webba da Silva
2012 Molecules  
Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleic acid structural studies by NMR. Four-stranded nucleic acid architectures studies increasingly benefit from a plethora of nucleotide conjugates for resonance assignments, the identification of hydrogen bond alignments, and improving the population of preferred species within equilibria. In this paper, we review their use for these purposes. Most importantly we identify reasons for the failure of some modifications to result in quadruplex formation.
doi:10.3390/molecules171113073 pmid:23128087 fatcat:zz6zoyoi65gbrdu532uqwhjpqu