New ST623 of Cryptococcus neoformans isolated from a patient with non-Hodgkin's lymphoma in the Brazilian Amazon

Lucyane Mendes Silva, William Antunes Ferreira, Roberto Alexandre Alves Barbosa Filho, Marcus Vinícius Guimarães Lacerda, Guilherme Motta Antunes Ferreira, Maria de Nazaré Saunier, Marielle Machado Macedo, Denise de Almeida Cristo, Marla Jalene Alves, Ani Beatriz Jackisch-Matsuura, Cristina Motta Ferreira
2020 Annals of Clinical Microbiology and Antimicrobials  
Cryptococcosis is a disease of wide geographic distribution. It is most critical when it affects immunocompromised patients, with AIDS, tuberculosis or other diseases that require prolonged hospitalization. This study described a case report, molecular epidemiology, the phylogenetic relationship, along with antifungal susceptibility test of a new ST 623 of C. neoformans isolated in a patient with non-Hodgkin's Lymphoma, from Manaus, Brazil. The new C. neoformans was susceptible to all
more » ... le to all antifungal drugs tested. Our results showed that ST623 new clone has no evident evolutionary proximity to any other ST of the VNI subtype group identified in Brazil. In the context of phylogenetic analysis, this new genotype belongs to VNI subtype, and subsequencing complete genome studies are necessary to better understand the phylogenetic relationships amongst STs in this group.
doi:10.1186/s12941-020-00361-3 pmid:32434527 fatcat:le6yyd7hbbdtlakqcz2lws5hya