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Diverse and non-coherent sets of epistemological principles currently inform research in the general area of functional genomics. Here, from the personal point of view of a scientist with over half a century of immersion in hypothesis driven scientific discovery, I compare and deconstruct the ideological bases of prominent recent alternatives, such as "discovery science," some productions of the ENCODE project, and aspects of large data set systems biology. The outputs of these types ofdoi:10.1353/pbm.2015.0025 pmid:26750600 fatcat:tpxw5j5hmvf73m5y5wvjju7cxu