Latent Space Arc Therapy Optimization [article]

Noah Bice, Mohamad Fakhreddine, Ruiqi Li, Dan Nguyen, Christopher Kabat, Pamela Myers, Niko Papanikolaou, Neil Kirby
2021 arXiv   pre-print
Volumetric modulated arc therapy planning is a challenging problem in high-dimensional, non-convex optimization. Traditionally, heuristics such as fluence-map-optimization-informed segment initialization use locally optimal solutions to begin the search of the full arc therapy plan space from a reasonable starting point. These routines facilitate arc therapy optimization such that clinically satisfactory radiation treatment plans can be created in about 10 minutes. However, current optimization
more » ... algorithms favor solutions near their initialization point and are slower than necessary due to plan overparameterization. In this work, arc therapy overparameterization is addressed by reducing the effective dimension of treatment plans with unsupervised deep learning. An optimization engine is then built based on low-dimensional arc representations which facilitates faster planning times.
arXiv:2106.05846v1 fatcat:hgdepv3q2jhz3fux7cyirx3v5q