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Models of rheumatoid arthritis (RA) in laboratory animals are important tools for research into pathogenic mechanisms and the development of effective, safe therapies. Rodent models (rats and mice) have provided important information about the pathogenic mechanisms. However, the evolutionary distance between rodents and humans hampers the translation of scientific principles into effective therapies. The impact of the genetic distance between the species is especially seen with treatments baseddoi:10.1186/ar1773 pmid:15987497 pmcid:PMC1175046 fatcat:x2opfytdcjaqzmd4eajhipgau4