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Immunogenicity of Renal Microvascular Endothelial Cells From Genetically Modified Pigs
Background. Disrupting the porcine GGTA1 and CMAH genes [double knockout (DKO)] that produce the gal-α(1,3)-gal and N-glycolylneuraminic acid xenoantigens reduces human antibody binding to porcine peripheral blood mononuclear cells. It is important to examine rejection pathways at an organ-specific level. The object of this study is to evaluate the human preformed antibody reactivity against DKO renal microvascular endothelial cells (RMEC) in vitro. Methods. Characteristics of DKO RMEC weredoi:10.1097/tp.0000000000001070 pmid:26906938 fatcat:vzyfrv3gmzguzm4uhhxbzieyuu