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Cell Cycle Remodeling and Zygotic Gene Activation at the Midblastula Transition
[chapter]
2016
Advances in Experimental Medicine and Biology
Following fertilization, vertebrate embryos delay large-scale activation of the zygotic genome from several hours in fish and amphibians to several days in mammals. Externally developing embryos also undergo synchronous and extraordinarily rapid cell divisions that are accelerated by promiscuous licensing of DNA replication origins, absence of gap phases and cell cycle checkpoints, and preloading of the egg with maternal RNAs and proteins needed to drive early development. After a
doi:10.1007/978-3-319-46095-6_9
pmid:27975277
fatcat:j73uoqk4ones5hx2nodwfo3g2a