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A major challenge in neuroscience is determining a quantitative relationship between the brain's white matter structural connectivity and emergent activity. We seek to uncover the intrinsic relationship among brain regions fundamental to their functional activity by constructing a pairwise maximum entropy model (MEM) of the inter-ictal activation patterns of five patients with medically refractory epilepsy over an average of ~14 hours of band-passed intracranial EEG (iEEG) recordings perdoi:10.1038/s42003-021-01700-6 pmid:33594239 pmcid:PMC7887247 fatcat:j4iqk63ukvdmnjtdi6wj6bpufy