Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: By sex status

Yang Zhou, Li-Wen Hu, Zhengmin (Min) Qian, Jen-Jen Chang, Chris King, Gunther Paul, Shao Lin, Pau-Chung Chen, Yungling Leo Lee, Guang-Hui Dong
2016 Environment International  
2016) Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: By sex status. Environment International, 94, This file was downloaded from: https://eprints.qut.edu.au/95732/ Abstract 1 Polyfluoroalkyl substances (PFASs) are a group of common chemicals that ubiquitously exist 2 in wildlife and humans. However, few studies have researched the effect of PFASs on 3 reproductive hormones in adolescents. To provide information in this regard, we recruited 4
more » ... d, we recruited 4 225 Taiwanese adolescents aged 13-15 years from 2009 to 2010 to investigate the 5 relationship between serum PFASs (PFOS, PFOA, PFBS, PFDA, PFDoA, PFHxA, PFHxS, 6 PFNA and PFTA) and reproductive hormone concentrations using a cross-sectional study 7 design. Results showed PFOS and PFTA levels were highest among the PFASs, with a 8 median concentrations of 29.9 (interquartile range: 13.0-43.8) ng/mL and 6.0 (0.6-25.9) 9 ng/mL in males, and a median concentrations of 28.8 (14.8-42.6) ng/mL and 4.5 (0.3-18.4) 10 ng/mL in females. After adjustment for confounding factors, nonsignificant associations 11 between PFASs and reproductive hormone were found except for PFNA with ln(estradiol) 12 (β=0.2060, 95%CI: 0.0016, 0.4105). When stratified by sex, more significant associations 13 were found in males than in females. Among males, PFASs were negatively associated with 14 ln(testosterone) level for PFOS (β=-0.0029, 95%CI: -0.0055, -0.0003), PFDA (β=-0.2565, 15 95%CI: -0.4135,-0.0994), PFHxA (β=-0.3095, 95%CI: -0.5942,-0.0248), and PFNA (β=-16 0.4233, 95%CI:-0.6998, -0.1467). Furthermore, male participant ln(estradiol) levels were 17 positively associated with PFOA (β=0.0921, 95%CI: 0.0186, 0.1656), and PFHxS (β=0.0462, 18 95%CI: 0.0020, 0.0905). Among females, a significant relationship was found only for 19 PFDoA with ln(testosterone) (β=-0.0119, 95%CI: -0.0227, -0.0010). In conclusion, this study 20 showed higher levels of PFASs coincide with lower testosterone and higher estradiol levels, 21 and more significant associations of PFASs with reproductive hormone were found in males 22 than in females. 23
doi:10.1016/j.envint.2016.05.018 pmid:27258660 fatcat:vx6drgs36beidalmalfuhxm7wa