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Background:Proliferative vitreoretinopathy (PVR) is a blind-causing disease initiated by the activation of retinal pigmented epithelium (RPE) primarily induced by TGF-β families. Migrasomes is a recently discovered type of extracellular vesicles related to cell migration. Results: Here, we used ex vivo, in vitro, and in vivo models, to investigate the characteristics and functions of migrasomes in RPE activation and PVR development. Results indicated that the migrasome marker tetraspanin-4doi:10.21203/rs.3.rs-1681948/v1 fatcat:o73qavgis5gxjamtt4cgrc5sza