Anti-inflammatory and antiradical potential of methanolic extract of Cajanus cajan

Ganga Raju M., Kumara Swamy K.
2018 Asian Journal of Pharmacy and Pharmacology  
Objective: The present study was carried out to investigate the anti-inflammatory and antioxidant activity of methanolic extract of . The extract was evaluated for its anti-Cajanus cajan in vivo Materials and Methods: inflammatory activity by carrageenan induced paw oedema model using indomethacin as standard and anti-in vitro inflammatory activity by protein denaturation method using diclofenac sodium as standard. The extract was evaluated for its antioxidant activity by reducing power assay
more » ... d hydrogen peroxide assay using ascorbic acid as standard. Results: The methanolic root extract of (MECC) significantly (p<0.05) inhibited the paw oedema Cajanus cajan volume. The extract significantly (p<0.05) protected protein membranes from denaturation. The extract also significantly scavenged the free radicals. The lupeol present in the extract targeted inflammatory signalling pathways there by exerting its anti-inflammatory activity. The phenolic constituents present in the extract might be responsible for its antioxidant activity as phenolics possess strong ability to inhibit oxidants and free radicals. From the Conclusion: above it is clear that MECC possess anti-inflammatory and antiradical activities.
doi:10.31024/ajpp.2018.4.6.21 fatcat:7etn7775endgzjlc6xxzbizt6u