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Protamine dosage effects on complement activation and sonoclot coagulation analysis after cardiac surgery
2013
Cardiovascular System
An optimal dosage and infusion regime for protamine reversal of heparin after cardiopulmonary bypass is important. Methods: Protamine dosages of either 2mg/kg or 4mg/kg bodyweight were compared in 40 patients after first time coronary arterial bypass grafting. Protamine was infused with a syringe driver over 20 minutes. Arterial blood sampling was performed prior to and during surgery, before and at 0.3, 0.6, 1, 3, 6 and 25h after the protamine infusion. C3a-desArg and C4a-desArg were analysed
doi:10.7243/2052-4358-1-1
fatcat:j4v65kgfn5czpbplpf4ffgiop4