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Structure-Based Drug Design for Cytochrome P450 Family 1 Inhibitors
2018
Bioinorganic Chemistry and Applications
Cytochromes P450 are a class of metalloproteins which are responsible for electron transfer in a wide spectrum of reactions including metabolic biotransformation of endogenous and exogenous substrates. The superfamily of cytochromes P450 consists of families and subfamilies which are characterized by a specific structure and substrate specificity. Cytochromes P450 family 1 (CYP1s) play a distinctive role in the metabolism of drugs and chemical procarcinogens. In recent decades, these
doi:10.1155/2018/3924608
pmid:30147715
pmcid:PMC6083639
fatcat:5hdcm4kyo5bd5aqqdhkjy3hpgi