Dietary Supplements for Prediabetes: A Systematic Review and Meta-analysis
Review question / Objective: To comprehensively assess the efficacy and safety of dietary supplements for prediabetes. Condition being studied: According to the International Diabetes Federation, the number of adults with impaired glucose tolerance or diabetes was 318 million and 415 million in 2015, respectively, and it is estimated that the number will rise to 482 million and 642 million in 2040. Compared with normoglycemic individuals, people with prediabetes have an increased risk of
... ased risk of coronary heart disease, composite cardiovascular disease, chronic kidney disease, stroke and developing type 2 diabetes mellitus(T2DM), causing severe physical impairment and heavy financial burden. While round 70% of prediabetic individuals eventually reach the irreversible diabetic endpoint, some of them do not convert to the diabetic stage and finally return to normoglycemia.  Hence, taking some effective measures at the pre-diabetic p h a s e s e e m s e s s e n t i a l . A s a n i m p o r t a n t f o r m o f complementary and alternative medicine(CAM), dietary supplements(DS) is defined as herbs or other botanicals, minerals, vitamins, enzymes, amino acid, and dietary substances. Using various dietary supplements is increasing steadily recently and relevant trials of different diseases are increasing correspondingly. Its effectiveness has been confirmed in some studies among prediabetic individuals. However, no comprehensive systematic reviews remain so far and we aim to collate the evidence on DS for prediabetes to evaluate its efficacy and safety. INPLASY registration number: This protocol was registered with the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) on 11 April 2020 and was last u p d a t e d o n 1 1 A p r i l 2 0 2 0 ( r e g i s t r a t i o n n u m b e r INPLASY202040057).