Validation of pulse wave velocity as a marker of arterial stiffness

Laura Tripkovic, Kathryn Hart, Gary Frost, John Lodge
2008 Proceedings of the Nutrition Society  
Arterial stiffness is an indication of structural and functional changes to the endothelium caused by factors such as aging or hypertensionrelated damage. Pulse wave velocity (PWV), a technique used to assess the extent of large artery elasticity and stiffness, has been proven to be an independent marker of CVD risk. Increases in PWV (particularly central) are linked to the presence of metabolic syndrome and a number of other associated CVD risk factors. PWV is a measure of the speed of the
more » ... e wave as it travels down the arterial tree after the ejection of blood into the ascending aorta. The higher the velocity of the wave, the less elastic the arterial walls, thus indicating increased arterial stiffness. This technique is simple and non-invasive, with reportedly good levels of reproducibility. The aim of the present study is to determine intra and inter-individual variation and establish predictive markers of PWV within a heterogenous population group to inform its use in research and clinical practice. PWV was performed on twenty-two males aged 21-56 years. All participants were normotensive, with a BMI range of 18.7-33.5 kg/ m 2 . All participants consumed a standard meal on the evening before the measurements session and then fasted for 12 h. Following a standardised operating procedure PWV measurements (peripheral (p) and central (c)) were recorded in duplicate within one session for each participant. Group (n 23) intra-individual variations for pPWV and cPWV, expressed as CV, were found to be 8.4 % and 5.9 % respectively. Only age was predictive for pPWV, accounting for 32 % of the variance (P = 0.002), whilst a model incorporating age and diastolic and systolic blood pressure accounted for 72 % of the variance in cPWV (P < 0.001). Younger males (21-30 years) had significantly lower pPWV (m/s; 7.0 (SD 1.31); P > 0.05) and cPWV (5.7 (SD 0.74); P > 0.001) than the older males (31-56 years; pPWV 8.8 (SD 1.14) m/s; cPWV 8.5 (SD 2.19) m/s). There was a significant correlation between cPWV and SBP (P = 0.02; Figure) .
doi:10.1017/s0029665108000566 fatcat:2llld5mxhvdgtf52w63dhxprcm