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Amplification of L-myc oncogene was noticed in a malignant meningioma originating from the right sphenoidal wing of a 54-year-old female. The patient underwent three surgical resections plus radiotherapy over a period of 11 years and then the growth rate of the tumor became much greater with a severely invasive appearance. Using Southern blot hybridization, L-myc amplification was examined on the specimen resected at the fourth operation. As a result , approximately five-fold amplification wasdoi:10.2176/nmc.31.1040 pmid:1726240 fatcat:kmf6qct27bhqjcwzjtuc5phzr4