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The identification of orthologs—genes in different species which descended from the same gene in their last common ancestor—is a prerequisite for many analyses in comparative genomics and molecular evolution. Numerous algorithms and resources have been conceived to address this problem, but benchmarking and interpreting them is fraught with difficulties (need to compare them on a common input dataset, absence of ground truth, computational cost of calling orthologs). To address this, the Questdoi:10.1093/nar/gkaa308 pmid:32374845 pmcid:PMC7319555 fatcat:fuzbeoshlvegddgzcylkiwvqpu