Comparing buspirone effect with the extract of borage (Echium amoneum L) flower on learning in adult male rats

Javid, Hoseini Se
Learning as one of the higher functions of the brain is affected by several factors. Anxiety disorders are among the factors result in learning disorders. Considering the side-effects of anxiolytics, this study aimed to compare the effects of buspirone with borage flower extract on learning in adult male rats. Materials and Methods: In this experimental study, adult male rats (no=40) were divided into 5 groups: Control, Sham and 3 Experimental groups (Buspirone 5 mg /kg, Borage extracts 150
more » ... ge extracts 150 mg/kg and Buspirone+extract). All injections were carried out intraperitoneally for 14 days. Conditioned Place Preference was used to assess the learning. Results: The results of Extract group showed a significant improvement after 7 days of drug injection (P≤0.05). In addition, a significant improvement was observed in Buspirone, Extract and Buspirone + Extract groups 14 days after drug injection. Conclusion: The results of the study showed that the buspirone and the borage augment the learning in rats.