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Iranian Journal of Neurology © 2017 Original Paper Molecular changes in obese and depressive patients are similar to neurodegenerative disorders
2017
Iran J Neurol
unpublished
Neurodegenerative disorders (NDs) are categorized as multifactorial conditions with different molecular and environmental causes. Disturbance of important signaling pathways, such as energy metabolism and inflammation induced by environmental agents, is involved in the pathophysiology of NDs. It has been proposed that changes in the lifestyle and nutrition (metabolism) during mid-life could trigger and accumulate cellular and molecular damages resulting in NDs during aging. Methods: In order to
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