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Multiple plasma proteins control atrial natriuretic peptide (ANP) aggregation
Journal of Molecular Endocrinology
We have recently demonstrated that human -atrial natriuretic peptide ( -hANP), an amyloidogenic peptide responsible for isolated atrial amyloidosis, binds to a dimeric form of apo A-I belonging to small high-density lipoproteins (HDL). This binding phenomenon is considered a protective mechanism since it inhibits or strongly reduces the ANP aggregation process. The observation that plasma exhibits at least four times greater amyloid inhibitory activity than HDL prompted us to determine whetherdoi:10.1677/jme.1.01530 pmid:15525593 fatcat:ldzrsxfgljaq5pebz3skghwb6u