In 2014 we published WHY OZONE THERAPY IN MULTIPLE SCLEROSIS? V. Simonetti, W. Liboni, F. Molinari, Rev. Esp.de OZONOTHERAPY Vol 4, N 1-2014 We have described the results observed on some MS patients treated with ozone therapy. Since then we have strengthened our knowledge on the etiopathogenetic mechanisms of MS and on the importance of the epigenetic factors that influence its manifestation and progression. By reating with OZONE different pathologies, not only in the neurological field, we

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... e expanded the knowledge on the ozone effects 1,2,3,9,10,11,17,18 : we have better understood why ozone therapy can be useful in patients with SM. Compared to what was published in 2014, despite the increase in the number of patients treated by us, from 43 to over 500, the short and long-term results obtained by us and by other colleagues who follow our protocol confirm what we had already published in 2014 12 and in the book we have published 8