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Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus
1995
Genetics
The agouti locus on mouse chromosome 2 encodes a secreted cysteine-rich protein of 131 amino acids that acts as a molecular switch to instruct the melanocyte to make either yellow pigment (phaeomelanin) or black pigment (eumelanin). Mutations that up-regulate agouti expression are dominant to those causing decreased expression and result in yellow coat color. Other associated effects are obesity, diabetes, and increased susceptibility to tumors. To try to define important functional domains of
doi:10.1093/genetics/140.1.255
fatcat:7cmzb7tttjaibhunvccvihegdy