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Characterization of long non-coding RNA-mediated competing endogenous RNA network to reveal potential long non-coding RNA biomarkers in rheumatoid arthritis patients under anti-TNF treatment
Int J Clin Exp Med
Objective: We designed to identify long non-coding RNA (lncRNA) signatures that predicted the therapy outcomes in rheumatoid arthritis (RA) via characterizing lncRNA-mediated competing endogenous RNA network (LMCN). Methods: Hypergeometric test was used to detect the competing lncRNA-mRNA interactions, following by co-expression analysis for the competing lncRNA-mRNA interactions relying on pearson correlation coefficient (PCC). The PCC absolute value of one interaction was defined as thefatcat:qwgvhp72ezdkriueemmkmp4jhe