THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND ANTITHROMBIN III IN THE PATHOGENESIS OF THE OVARIAN HYPERSTIMULATION SYNDROME

E Kovachev, I Kozovski, V Markova, K Aleksandrov, S Cherneva, S Cvetkova
2003 Scripta Scientifica Medica   unpublished
Ovarian hyperstim ulation syndrom e (O H SS) is an iatrogenic com plication o f controlled ovarian hyperstim ulation (C O H). Its pathogenesis is not clarified yet. In the recent years a num ber o f studies focused on the vascular endothelial growth factor (V E G F) and antihtrom bin III (AT III) indicators. V E G F is hom odim eric, heparin-binding glycoprotein, stim ulating vascular perm eability. A ntithrom bin III is protease inhibitor o f activated clotting factors. This study aim ed at
more » ... study aim ed at exam ining the V E G F-A 165 and AT III indicators with two O H SS patients. Tw o m ethods w ere used for the determ ination o f the indicators o f VEG F-Aies and AT III: ELISA for V E G F and chrom ogenic assay for ATT III. Kits o f R/D System s and A m ericanD iagnostica Inc. w ere used to estim ate V EG F and AT III indicators in serum and plasm a. There w ere higher indicators o f V E G FA 165 (180pg/m l) and reduction o f AT III indicators (48%) in the patient with a severe form o f OHSS than in the control group w hile these indicators w ere norm al in the patient with a m oderate form o f OHSS. O ur results confirm ed som e published data concerning the im portance o f V E G F and AT III in the genesis o f OH SS. This study should include a larger group o f patients in order to follow-up statistically and authentically the variations o f the indicators o f both factors and their im portance for OHSS.
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