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Antimicrobial Therapy for Chronic Osteomyelitis in Adults: Role of the Quinolones
Clinical Infectious Diseases
The development of antimicrobial therapy for osteomyelitis is reviewed. The disease, especially when chronic, is notoriously resistant to antibiotic therapy. The duration of disease defining chronicity has decreased considerably in the last 30 years. Successful therapy reflects increased appreciation of the combined roles of surgical debridement and prolonged antimicrobial courses. Parenteral highdose b-lactam agents yield clinical success for many patients with chronic osteomyelitis,doi:10.1086/516150 pmid:9431371 fatcat:7ipykho47zaqpk22d2v4fe74uq