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Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown
1994
Journal of Immunology
Two approaches have been used to assess the hypothesis that granzymes secreted by cytotoxic lymphocytes act within the target cells to trigger an internal disintegration pathway leading to target cell lysis. The lytic properties of several clones of rat basophilic leukemia cells transfected with either cytolysin (perforin) alone (RBL-cy) or a combination of cytolysin and granzyme A (RBL-cy-gza) were compared with cloned CTL. Analysis of the kinetics of target cell 125I-DNA vs 51Cr release with
doi:10.4049/jimmunol.152.3.1057
fatcat:zo4lb4ew5ngwjmqunrmgvccusi