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This work investigates the metabolic origin of triacylglycerol (TAG) formed during lipid droplet (LD) biogenesis induced by stress. Cytotoxic inhibitors of fatty acid synthase induced TAG synthesis and LD biogenesis in CHO-K1 cells, in the absence of external sources of fatty acids. TAG synthesis was required for LD biogenesis and was sensitive to inhibition and down-regulation of the expression of group VIA phospholipase A 2 (iPLA 2 -VIA). Induction of stress with acidic pH, C 2 -ceramide,doi:10.1074/jbc.m806173200 pmid:19117952 fatcat:5xhqpxvn7vcabhdajl55br7zkm