Faculty of 1000 evaluation for An inherently bifunctional subset of Foxp3(+) T helper cells is controlled by the transcription factor Eos [dataset]

Maripat Corr
2013 F1000 - Post-publication peer review of the biomedical literature   unpublished
At sites of inflammation, certain regulatory T cells (Treg cells) can undergo rapid reprogramming into helper-like cells, without loss of the transcription factor Foxp3. We show that reprogramming is controlled by down-regulation of the transcription factor Eos (Ikzf4), an obligate co-repressor for Foxp3. Reprogramming was restricted to a specific subset of "Eoslabile" Treg cells which were present in the thymus and identifiable by characteristic surface markers and DNA methylation. Mice made
more » ... ficient in this subset became impaired in their ability to provide help for presentation of new antigens to naive T cells. Down-regulation of Eos required the proinflammatory cytokine IL-6, and mice lacking IL-6 had impaired development and function of the Eos-labile subset. Conversely, the immunoregulatory enzyme IDO blocked loss of Eos, and prevented the Eos-labile Treg cells from reprogramming. Thus, the Foxp3 + lineage contains a committed subset of Treg cells capable of rapid conversion into biologically important helper cells.
doi:10.3410/f.718011444.793477988 fatcat:xnhlefbk4bcg3lr6vaak72ynwq