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F1000 - Post-publication peer review of the biomedical literature
At sites of inflammation, certain regulatory T cells (Treg cells) can undergo rapid reprogramming into helper-like cells, without loss of the transcription factor Foxp3. We show that reprogramming is controlled by down-regulation of the transcription factor Eos (Ikzf4), an obligate co-repressor for Foxp3. Reprogramming was restricted to a specific subset of "Eoslabile" Treg cells which were present in the thymus and identifiable by characteristic surface markers and DNA methylation. Mice madedoi:10.3410/f.718011444.793477988 fatcat:xnhlefbk4bcg3lr6vaak72ynwq