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Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state
The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD225 family and inhibit diverse virus infections. IFITM3 reduces membrane fusion between cells and virions through a poorly characterized mechanism. We identified a GxxxG motif in many CD225 proteins, including IFITM3 and proline rich transmembrane protein 2 (PRRT2). Mutation of PRRT2, a regulator of neurotransmitter release, at glycine-305 was previously linked to paroxysmal neurological disorders in humans. Here,doi:10.1101/2020.05.14.096891 fatcat:4asjtbjrbrcrvigmhl5k73rvye