Inter-patient Variability in Clinical Efficacy of Metformin in Type 2 Diabetes Mellitus Patients in West Bengal, India

Biswabandhu Bankura, Madhusudan Das
2016 Journal of Metabolic Syndrome  
and objective: Metformin is often used as a first-line therapy for Type 2 diabetes mellitus (T2DM), but the glycemic response to metformin is variable in patients. Here, we aimed to assess the inter-patient variability in terms of glycemic response to metformin in the state of West Bengal, India. Material and methods: We enrolled newly diagnosed treatment naïve 113 patients with T2DM. Patients were subjected to assay of glycated hemoglobin (HbA1c), fasting blood glucose (FBG), postprandial
more » ... , postprandial blood glucose (PP) and measurement of body mass index (BMI), waist circumstances (WC) before and after the end of 3 months of immediate release metformin (2000mg/day) therapy. Results: Out of 113 patients, 111 (58 male and 53 female; average age 43.13 years) were provided with 3 months of metformin therapy. 102 individuals responded to metformin, but HbA1c levels of 9 patients did not improve after 3 months of drug therapy. Conclusions: In the present study, metformin lead to improvements in glycemic control in 92% of newly diagnosed T2DM patients but in 8% does not which is much less in this part of India. Hypertension 26 (23.4) Osmotic symptoms 57 (51.3) Polyphagia 17 (15.3) Gen weakness 25 (22.2) Weight loss 8 (7.2) Burning sensation in feet and palm 8 (7.2) Numbness in feet 3 (2.7) Pruritus 4 (3.6) Balanoposthitis 4 (3.6) Vaginitis 2 (1.8)
doi:10.4172/2167-0943.1000198 fatcat:nfer5dlzova27mpeyhwx2l2jjq