The candidate proto-oncogene bcl-3 encodes a protein that shares structural features with IKB-~ and other proteins that bind to members of the Rel protein family. Here, we show that in contrast to the inhibitory activity of IKB-a, the bcl-3 gene product superactivates NF-KB p50 homodimer-mediated gene expression both in vivo and in vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence of DNA containing a KB motif. These results strongly suggest that BCL-3

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... an act as a transcriptional coactivator, acting through DNA-bound pS0 homodimers. [Downloaded from Access the most recent version at doi: 7: 1993, Genes Dev. T Fujita, G P Nolan, H C Liou, et al. coactivator that activates through NF-kappa B p50 homodimers. The candidate proto-oncogene bcl-3 encodes a transcriptional References http://genesdev.cshlp.org/content/7/7b/1354.full.html#ref-list-1