Electrochemical investigations of unexplored anthraquinones and their DNA binding

Afzal Shah, Abdur Rauf, Asad Ullah, Azeema Munir, Rumana Qureshi, Iftikhar Ahmad, Muhammad Tahir Soomro, Zia-Ur Rehman
2013 Journal of Electrochemical Science and Engineering  
The redox behaviour of two potential anticancer anthraquinones, 9,10-anthraquinone and 2-chloromethyl-9,10-anthraquinone was investigated in a wide pH range. Cyclic voltammetry based assay was developed for the assessment of the effect of medium, substituents, potential scan rate and number of scans on the voltammetric response of anthraquinones. The electrode reaction mechanism was suggested on the basis of cyclic and differential pulse voltammetric results. The effect of DNA on anthraquinones
more » ... was also probed at physiological pH which could lead to further investigation of possible citotoxic activity in vitro. The results revealed that anthraquinones interact with DNA more strongly than the clinically used anticancer drug, epirubicin.
doi:10.5599/jese.2012.0026 fatcat:e64ntp4rcrfxrlvhaxfnlgoree