Internet Archive Scholar

Electrochemical investigations of unexplored anthraquinones and their DNA binding

Afzal Shah, Abdur Rauf, Asad Ullah, Azeema Munir, Rumana Qureshi, Iftikhar Ahmad, Muhammad Tahir Soomro, Zia-Ur Rehman
2013 Journal of Electrochemical Science and Engineering  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (910.3 kB)
https://web.archive.org/web/20171202211523/http://www.jese-online.org/Articles/Vol_03/No_1/Pdf/jESE_Vol3_No1_p19-27_2013.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL. The file type is application/pdf.

The redox behaviour of two potential anticancer anthraquinones, 9,10-anthraquinone and 2-chloromethyl-9,10-anthraquinone was investigated in a wide pH range. Cyclic voltammetry based assay was developed for the assessment of the effect of medium, substituents, potential scan rate and number of scans on the voltammetric response of anthraquinones. The electrode reaction mechanism was suggested on the basis of cyclic and differential pulse voltammetric results. The effect of DNA on anthraquinones
more » ... was also probed at physiological pH which could lead to further investigation of possible citotoxic activity in vitro. The results revealed that anthraquinones interact with DNA more strongly than the clinically used anticancer drug, epirubicin.
doi:10.5599/jese.2012.0026 fatcat:e64ntp4rcrfxrlvhaxfnlgoree
DOAJ OJS
Citation

Afzal Shah, Abdur Rauf, Asad Ullah, Azeema Munir, Rumana Qureshi, Iftikhar Ahmad, Muhammad Tahir Soomro, Zia-Ur Rehman. "Electrochemical investigations of unexplored anthraquinones and their DNA binding." Journal of Electrochemical Science and Engineering (2013)