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Causal Associations of Urate With Cardiovascular Risk Factors: Two-Sample Mendelian Randomization
2021
Frontiers in Genetics
BackgroundMendelian Randomization (MR) studies show conflicting causal associations of genetically predicted serum urate with cardiovascular risk factors (i.e., hypertension, diabetes, lipid profile, and kidney function). This study aimed to robustly investigate a causal relationship between urate and cardiovascular risk factors considering single nucleotide polymorphisms (SNPs) as instrumental variables using two-sample MR and various sensitivity analyses.MethodsData on SNP-urate associations
doi:10.3389/fgene.2021.687279
pmid:34306027
pmcid:PMC8297413
fatcat:6eytncbvnbglpdf2enlhpstbqi