CDC25A Phosphatase: a Rate-Limiting Oncogene That Determines Genomic Stability

D. Ray, H. Kiyokawa
2008 Cancer Research  
CDC25A is a critical regulator of cell cycle progression and checkpoint response. Overexpression of this cyclin-dependent kinase phosphatase occurs often in human cancers. Our recent genetic studies in the mouse indicate that restricting CDC25A can limit tumorigenesis induced by the HER2/neu-RAS oncogenic pathway without compromising normal cell division or viability. These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy.
doi:10.1158/0008-5472.can-07-5983 pmid:18316586 fatcat:gkj7slxvu5cfdh35fthl7tr75q