Objective Materials and : To explore the wound healing activity of leaf extract (Gentianaceae). Enicostema littorale Methods: Ethanolic leaf extract and its active secoiridoid, Swertiamarin are used for this study. There is a significant wound healing activity observed for the group of Wistar rats treated with Swertiamarin. Scientific cure is proven by measuring the wound area in each test group animals from 0 to 15 days. : The topical application of ethanolic Results extract and Swertiamarin

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... ntment results in decrease of the wound area in 15 days. Swertiamarin is effective in comparison with crude ethanolic extract. Biological estimation also proved that the Swertiamarin treated group had a high percentage of wound contraction score than the control group. : Swertiamarin formulated herbal Conclusion ointment is an efficient cutaneous ointment for wound healing activity in excision animal models.