Significance of Non HDL-cholesterol and Triglyceride to HDL-cholesterol Ratio as Predictors for Metabolic Syndrome among Korean Elderly
Korean Journal of Clinical Laboratory Science
충북보건과학대학교 임상병리과, 2 신성대학교 임상병리과 We evaluated the possible clinical application of Non HDL-cholesterol and triglyceride to HDL-cholesterol ratio as a metabolic syndrome predictor for the elderly in Korea. 1,543 elderly persons aged 65 years or older who visited the health examination center of Gyeonggi Regional General Hospital from January 2015 to December 2017 and had a health checkup were enrolled in this study. Metabolic syndrome was diagnosed based on the American Heart Association/National
... eart, Lung, and Blood Institute (AHA/NHLBI) standards. Abdominal obesity was assessed by the Asia-Pacific standards presented at the World Health Organization (WHO) West Pacific Region. Non-HDL-cholesterol was calculated as the difference between total cholesterol and HDLcholesterol. The metabolic syndrome predictive power was higher for triglyceride to HDLcholesterol ratio than for Non HDL-cholesterol. After correcting for related factors, triglyceride to HDL-cholesterol ratio was higher in the 4 th quartile, which had a higher risk of developing metabolic syndrome, than in the 1 st quartile. The optimal cutoff value for the triglyceride to HDL-cholesterol ratio that predicts the onset of metabolic syndrome was 2.8. triglyceride to HDL-cholesterol ratio can be a simple and practical indicator of the risk of metabolic syndrome. 서 론 대사증후군은 고혈압, 내당능장애, 이상지질혈증, 복부비만 의 심혈관계 위험요인들이 군집되어 나타나는 현상으로 공통된 원인은 인슐린저항성으로 보고되고 있다. 국민건강영양조 사 자료를 바탕으로 우리나라의 대사증후군 유병률은 1998년 남성 13.5%, 여성 15.0% 였으나, 2009년 남성 28.3%, 여성 16.6%로 증가하는 추세이다. 노인의 대사증후군 유병률은 2007년 국민건강영양조사 자료를 통해 남성 21.7%, 여성 46.7%로 남성보다 여성에서 연령 증가와 함께 큰 폭의 증가를 보이며, 이러한 국내 노인의 대사증후군 유병률은 유럽에 비 해 높은 실정이다[4, 5].