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AB0072 Rational designed gold nanoparticle suppresses rankl-induced osteoclastogenesis in raw264.7 cells via NF-KAPPA B pathway and MAPK pathways
Abstracts Accepted for Publication
Bone erosion in joint is the most deleterious effect induced by rheumatoid arthritis (RA) and is the major cause of disability. New therapies are urgently required to prevent RA-associated bone destruction. The excessive bone resorption in RA was proved to be mediated by osteoclasts which are derived from the monocyte/macrophage lineage and induced by RANKL. Therefore, RANKL could be a potential target for the preservation of bone mass in RA. Objectives: Chrysotherapy showed potential effectsdoi:10.1136/annrheumdis-2017-eular.2087 fatcat:ezrk5msocrcbxhzwm3fdtvhgka