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Overexpression of GRK2 in vascular smooth muscle leads to inappropriate hypertension and acute heart failure as in Clinical Scenario 1
[post]
2022
unpublished
Clinical scenario 1 (CS1) is acute heart failure (HF) characterized by transient systolic blood pressure (SBP) elevation and pulmonary congestion. Although it is managed by vasodilators, the molecular mechanism remains unclear. The sympathetic nervous system plays a key role in HF, and desensitization of cardiac β-adrenergic receptor (AR) signaling due to G protein-coupled receptor kinase 2 (GRK2) upregulation is known. However, vascular β-AR signaling that regulates cardiac afterload remains
doi:10.21203/rs.3.rs-2313136/v1
fatcat:myqh52wkdrbmjauvxb4jejr4zu