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Identification and characterization of two functional variants in the human longevity gene FOXO3
2017
Nature Communications
FOXO3 is consistently annotated as a human longevity gene. However, functional variants and underlying mechanisms for the association remain unknown. Here, we perform resequencing of the FOXO3 locus and single-nucleotide variant (SNV) genotyping in three European populations. We find two FOXO3 SNVs, rs12206094 and rs4946935, to be most significantly associated with longevity and further characterize them functionally. We experimentally validate the in silico predicted allele-dependent binding
doi:10.1038/s41467-017-02183-y
pmid:29234056
pmcid:PMC5727304
fatcat:xdqocw7xdbfxnmyrhqmqsk6dm4