Male Circumcision and Serologically Determined Human Papillomavirus Infection in a Birth Cohort

N. P. Dickson, J. Ryding, T. van Roode, C. Paul, P. Herbison, J. Dillner, D. C.G. Skegg
2009 Cancer Epidemiology, Biomarkers and Prevention  
Circumcision has been reported to protect against infection with human papillomavirus (HPV) in men, but results have been inconsistent. We followed males in a birth cohort born in Dunedin, New Zealand, in 1972 and 1973 from age 3 to 32 years. Seropositivity at age 32 years for the oncogenic types HPV-16 and 18, and the nononcogenic types 6 and 11, was studied in relation to maternal reports of circumcision status at age 3 for 450 men. Seropositivity to any of these types was associated with
more » ... associated with lifetime number of sexual partners (P = 0.03), and lower moral-religious emphasis of the family of origin (P < 0.001). Circumcision was not found to be protective, with the adjusted odds ratio (95% confidence interval) for HPV6/11/16/18 seropositivity among the circumcised compared with the uncircumcised being 1.4 (0.89-2.2).
doi:10.1158/1055-9965.epi-08-0353 pmid:19124496 fatcat:tusoqaj6jfeexmzzzyvvdyrfhq