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Dopaminergic dysfunction in neuropsychiatric disorders. Pathophysiology, current therapeutics, and future perspectives
2019
Neuropsychiatria i Neuropsychologia
A b s t r a c t Dopaminergic signalling is crucial for a variety of brain functions, and abnormal dopamine regulation leads to neuropsychiatric disorders. Dopamine (DA) receptors are members of the G protein-coupled receptors (GPCRs) superfamily, with seven transmembrane spanning domains. DA, upon release from pre-synaptic neurons, activates dopamine receptor subtypes D1 to D5 and induces Gαs/olf-and Gαi/o-mediated intracellular signalling. Defects in DA signalling cause either over-activation
doi:10.5114/nan.2019.87724
fatcat:qqyigwskzbfvhmstca54oijk7u