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Molecular basis of specific viral RNA recognition and 5′-end capping by the Chikungunya virus nsP1
2022
Cell Reports
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Many viruses encode RNA-modifying enzymes to edit the 5' end of viral RNA to mimic the cellular mRNA for effective protein translation, genome replication, and evasion of the host defense mechanisms. Alphavirus nsP1 synthesizes the 5' end Cap-0 structure of viral RNAs. However, the molecular basis of the capping process remains unclear. We determine high-resolution cryoelectron microscopy (cryo-EM) structures of Chikungunya virus nsP1 in complex with m7GTP/SAH, covalently attached m7GMP, and
doi:10.1016/j.celrep.2022.111133
pmid:35905713
fatcat:qpthgl3mgzgzlejncx26jxx2xm