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The kinetics of recovery after inhibition of growth by erythromycin and clarithromycin were examined in Staphylococcus aureuscells. After inhibition for one mass doubling by 0.5 μg of the antibiotics/ml, a postantibiotic effect (PAE) of 3 and 4 h duration was observed for the two drugs before growth resumed. Cell viability was reduced by 25% with erythromycin and 45% with clarithromycin compared with control cells. Erythromycin and clarithromycin treatment reduced the number of 50S ribosomaldoi:10.1128/aac.43.6.1324 fatcat:cruoqvublvbdxatd5lxkenm6nm