Effect of Sindbis virus infection on induction of heat shock proteins in Aedes albopictus cells

J Tatem, V Stollar
1989 Journal of Virology  
When Aedes albopictus cells (clone C7) were infected with Sindbis virus, the production of cytopathic effect CPE depended largely on the conditions under which the cells were cultured. We observed marked inhibition of cellular RNA and protein synthesis, as well as a loss of the ability to induce heat shock proteins, e.g., hsp7O, under conditions which led to cytopathic effect. Infected cells in which heat shock proteins could no longer be induced contained much lower amounts of hsp7O mRNA after
more » ... of hsp7O mRNA after heat shock than did mock-infected cells which were similarily treated. It is suggested that this decreased level of hsp7O mRNA is due to a failure of these cells to synthesize hsp7O mRNA after heat shock.
doi:10.1128/jvi.63.2.992-996.1989 fatcat:wgiohdgubrb3phhwfqdpifi6zm